ALIPHATIC AND ARYLALIPHATIC ETHERS OF 5,7-DIHALOGEN-8- HYDROXYQUINOLINES AND THEIR PERCHLORATES AS POTENTIAL NUTRITIVE AND ANTICOCCIDIAL REMEDIES

A. Pavlov, N. V. Georgieva, Z. Yaneva, L. Dospatliev, V. Koinarski

Abstract: The determination of the anticoccidial activity of eight newly synthesized derivatives of substituted 8-
hydroxyquinolines was carried out with 21-day-old chicken broilers, Cornish х Plymouthrock breed. According
to the obtained screening results, two of the newly synthesized compounds: ethyl 2-(5,7-dichloro-
2-methylquinoline-8-yloxy)acetate /3.1/ and 5,7-dichloro-2-methyl-8-(4-nitrobenzyloxy) quinoline /3.3/,
displayed anticoccidial activity and stimulated the livе weight increase of infected and healthy chickens, at
350 ppm draughts. The highest anticoccidial activity was shown for compound /3.1/ (anticoccidial index-
ACI = 95.1), at the highest chicken survival percent (SP=100%), equal to that of the non-invaded chickens
control group without the addition of the investigated compounds to their food. A high SP was also observed
for compounds: 5,7-dichloro-2-methyl-8-(4-nitrobenzyloxy)quinoline /3.3/ 90 %, 5,7-dibromo-8-
(4-nitrobenzyloxy)quinoline /3.4/ 80 % and for ethyl 2-(5,7-dibromoquinolin-8-yloxy)acetate perchlorate /
3.7/ 80 %. The lowest anticoccidial activity (ACI = 32.4) was determined for ethyl 2-(5,7-dibromoquinoline-
8-yloxy)butanoate perchlorate /3.8/.

Keywords: 8-hydroxyquinoline; anticoccidial preparations; chlorquinaldol; Eimeria tenella; ethers; perchlorates

Date published: 2022-08-12