Field trials to establish the clininical equivalence of two 34 injectable solutions of nitroxinil in sheep, cattle and buffalo naturally infected with Fasciola hepatica and certain gastrointestinal nematodes

Metodi Petrichev

Abstract: The clinical equivalence in the field of two 34% injectable solutions of nitroxynil - Nitroxinil 34%
solution for injection - ”Investigation product” and Trodax 34% inj. sol. - ”Control product” in sheep,
cattle and buffaloes naturally infected with Fasciola hepatica and some gastrointestinal nematodes.
In each experiment three groups were formed – two experimental and one control. The experiments
were performed to compare and possibly confirm the clinical equivalence between the preparation
Nitroxinil 34% inj. sol. and the original Trodax product 34%. A total of 126 sheep of the Local
Improved breed were used, with a body weight of 40–50 kg, mostly female and of different ages. In
the experiments with cattle, 60 cattle from the cross X Local Chernoshareno and 30 buffaloes of the
breed ”Murrah”, of female sex with different live weight, were used. The test and control product
was administered at a dose of 10 mg/kg bw. or 1 ml for 34 kg m.p. Sheep, cattle and buffaloes were
injected once subcutaneously. In terms of its effectiveness, Nitroxinil 34% solution for injection does
not differ from the original product Trodax (P > 0.05), which leads to the conclusion that the two
preparations are equivalent in terms of their clinical efficacy.
The aim of the present study was to conduct a comparative clinical study of these two veterinary
medicinal products in terms of their efficacy.

Keywords: buffalo; cattle; clininical equivalence; sheep; two 34 injectable solutions of nitroxinil

Date published: 2021-12-22