ENDOGENOUS COMPOUNDS AND RECEPTOR SYSTEMS RELATED TO THE BIOLOGICAL PHENOMENON SLEEP

D. Mladenov, Y. Iliev

Abstract: This review article, presents data from modern scientific research publications, about this biological phenomena, that shows different and various mechanisms, changes, differences and receptor relationship interactions in biochemical, bioelectrical and neurophysiological field. Described are endogenous compounds and receptor systems in which the research results are most important and impressive. The main focus is on the specific nerve centers and fields in brain related to this biological phenomenon, ircadian
rhythms, REM and NREM stages, melatonin, serotonin, orexine, gamma-aminobutyric acid, the specific receptors associated with them, and information about pathological sleep states associated with these plastic mechanisms. The depths of the interneuron relationships and processes are not fully understood, as well as the endogenous receptor changes during different cyclical phases of sleep. Explaining and solving these problems is a basis for fundamental discoveries in modern science.

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Date published: 2017-02-08