CELL ELEMENTS AND INNATE DEFENSE MECHANISMS IN DOGS WITH MANDIBULAR BONE DEFECTS REPAIRED BY GUIDED BONE REGENERATION AND TITANIUM DENTAL IMPLANTS

M. Andonova, I. Borissov, M. Paskalev, N. Uzunov

Abstract: The purpose of the study was to investigate the effect that mandibular bone defects in dogs and the
procedure of their repair had on the natural systemic mechanisms of defense. Readily available and highly
informative cellular and humoral factors of resistance were analyzed (total and differential white blood cell
counts, phagocytic activity of neutrophils, metabolic activity of phagocytes - NBT test, total protein and
protein fractions, fibrinogen). They were monitored in the post operative period (hours 24, 48, 72 and
month 1) in 6 clinically healthy, sexually mature mixed-breed dogs from both genders at the age of 2-6 years
weighing 10-18 kg. It was found that the performed operative interventions in the buccal cavity of the dogs
did not challenge significantly the systemic innate mechanisms of defense. The most easily available factors
of innate resistance were the phagocytic and metabolic activities of neutrophils, and fibrinogen concentrations
that exhibited statistically significant changes up to the 72nd hour. Тhe application of titanium dental
implants and the combined technique for guided bone regeneration did not induce acute reactions of rejection
on the part of the recipient, thus allowing their use in both veterinary and human dentistry.

Keywords: dogs; NBT-test; neutrophils; phagocytosis; titanium implants

Date published: 2022-08-12